Evaluation of the effect of adding ketamine in dose reduction of morphine with patient-controlled analgesia pump in postoperative analgesia after major abdominal surgery

Evaluation of the effect of adding ketamine in dose reduction of morphine with PCA pump in postoperative analgesia after major abdominal surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112128384N1

Enrollment

115

Registered

2012-05-31

Start date

2012-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after abdominal surgery.

Interventions

Intervention 1: Adding intravenous ketamine to Morphine PCA in MK group. Intervention 2: Only Morphine PCA to control group.

Treatment - Drugs

Adding intravenous ketamine to Morphine PCA in MK group

Only Morphine PCA to control group

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: • Adult patients who undergo midline laparotomy Exclusion Criteria • Patients with pain disorder • Consumption of any narcotics and analgesics within a week before surgery • Narcotics addicts • Any contraindication in consumption of paracetamol, morphine or ketamine • Consumption of psychotropic drugs • Any non-midline incision or below umbilicus incisions • Surgical procedures with pelvic tissue manipulation • Noncompliant patients

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain Intensity. Timepoint: Every 2 hours for 6 hours and then every 6 hours up to 48 hours. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Delirium. Timepoint: During the first 48 hours at ward post operatively. Method of measurement: ICU_CAM scale.;Pain location. Timepoint: During the first 48 hours at ward post operatively. Method of measurement: Subjectively by patient.;Morphine side effects-Nausea. Timepoint: Within the first 24 hours after intervention. Method of measurement: Times of nausea.;Morphine side effects_Respiratory suppression. Timepoint: Within the first 48 hours after intervention. Method of measurement: Respiratory rate.;Incision location. Timepoint: After operation. Method of measurement: Anatomical description.;Operating time. Timepoint: Duration between induction and end of general anaesthesia. Method of measurement: Minutes.;Reason for surgical procedure. Timepoint: After operation. Method of measurement: Benign_Malignant, Explorative, Acute_Chronic, NOS.	—

Measure

Time frame

Delirium. Timepoint: During the first 48 hours at ward post operatively. Method of measurement: ICU_CAM scale.;Pain location. Timepoint: During the first 48 hours at ward post operatively. Method of measurement: Subjectively by patient.;Morphine side effects-Nausea. Timepoint: Within the first 24 hours after intervention. Method of measurement: Times of nausea.;Morphine side effects_Respiratory suppression. Timepoint: Within the first 48 hours after intervention. Method of measurement: Respiratory rate.;Incision location. Timepoint: After operation. Method of measurement: Anatomical description.;Operating time. Timepoint: Duration between induction and end of general anaesthesia. Method of measurement: Minutes.;Reason for surgical procedure. Timepoint: After operation. Method of measurement: Benign_Malignant, Explorative, Acute_Chronic, NOS.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Arash Peivandi Yazdi

Mashhad University of Medical Sciences

PeivandiA@mums.ac.ir; surg.rc@mums.ac.ir+98 51 1802 2677

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026