Comparison of ketamine and methadone in pain control of addicts after surgery

Comparison of analgesic effect of low dose of ketamine vs. methadone on opioid abusers undergoing surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111212008384N8

Enrollment

220

Registered

2022-02-24

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain.

Interventions

Intervention 1: Intervention group: Ketamine will be administered in the ICU 0.5 mg per kg every 6 hours intravenously. Intervention 2: Control group: In the control group, 5 mg of methadone is admini

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Addicted patients who are candidates for GA abdominal surgery require special postoperative care Age between 20 to 65 years History of daily drug use for the past 6 months

Exclusion criteria

Exclusion criteria: Known drug allergy to ketamine or methadone History of hypertension or PAP History of severe systemic disease History of psychiatric illness high ICP History of alcohol and psychotropic substances Prohibition of intramuscular injection Pregnancy

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: At the beginning, every 3 hours, after 24 hours. Method of measurement: Using the Verbal Scoring System (NRS) we will use zero as the minimum and 10 as the maximum number of pain.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Arash Peivandi Yazdi

Mashhad University of Medical Sciences

PeivandiA@mums.ac.ir+98 51 1802 2677

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026