Effect of Dexamethasone on prophylaxis of nausea and vomiting after laparoscopic cholecystectomy

Evaluation of prophylactic anti-emetic effect of Dexamethasone in patients undergoing elective laparoscopic cholecystectomy in comparison with Metoclopramide and placebo.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112088329N1

Enrollment

160

Registered

2012-01-06

Start date

2010-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Nausea and Vomiting after cholecystectomy. Condition 2: Post-Operative Vomiting. Postcholecystectomy syndrome Vomiting following gastrointestinal surgery

Interventions

Intervention 1: Ampul Dexamethasone 8 mg IV for intervention group. Intervention 2: Ampul Metoclopramide 10mg IV for control group. Intervention 3: Ampul Normal Saline (0.9%) IV.

Prevention

Placebo

Ampul Dexamethasone 8 mg IV for intervention group

Ampul Metoclopramide 10mg IV for control group

Ampul Normal Saline (0.9%) IV

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients and age ranging 18 to 60 years who undergo general anesthesia for elective laparoscopic cholecystectomy in Mostafa Khomeini hospital. Exclusion criteria: Patients who have a history of motion sickness; Patients who have any intestinal diseases ;Patients who had received any anti-emetic agents within 24h before surgery; pregnant or breast-feeding women; patients who have evidence of hepatic dysfunction

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Episodes of post-operative Vomit. Timepoint: Time 0 until 24 hours after recovery form General anesthesia. Method of measurement: Asking from patients.	—

Secondary

Measure	Time frame
Sensation of post-operative nausea. Timepoint: 0 -24 hours after recovery from general anesthesia. Method of measurement: visual scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmin Mohamadi

Tehran University of Medical Science

a_mohamadi@student.tums.ac.ir+98 21 6649 5948

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026