Effect of Folic acid and Levothyroxine versus Levothyroxine on serum Homocysteine value in patients with hypothyroidism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112077723N1

Enrollment

Registered

2011-12-07

Start date

2009-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothyroidism. Hypothyroidism, unspecified

Interventions

Intervention 1: Control group: Placebo per day for 8 weeks. Intervention 2: intervention group: 50-100 mg Levothyroxine and Folic acid (1mg/day) per day for 8 weeks.

Placebo

Treatment - Drugs

Control group: Placebo per day for 8 weeks

intervention group: 50-100 mg Levothyroxine and Folic acid (1mg/day) per day for 8 weeks

Eligibility

Sex/Gender

All

Age

29 Years to 37 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Hypothyroidism, Natural kidney function, TSH>10mIU/L Exclusion criteria: use of drugs such as Phenobarbital, Phenytoin, Tamoxifen, Methotrexate, Theophylline, diabetic, pregnancy, smokers

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The decrease of serum homocysteine. Timepoint: Every two months. Method of measurement: EAI.	—

Secondary

Measure	Time frame
The decrease of atherosclerosis. Timepoint: Every two months. Method of measurement: Every two months.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNader Hajibagher Tehrani

Metabolic Diseases Research Center, Qazvin University of Medical Sciences

nhbtehrani@qums.ac.ir nhbtehrani@yahoo.com+98 28 1336 0084

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026