A randomized clinical trial comparing the effect of methylprednisolone and dexamethasone pulse in the control of rheumatoid arthritis flare up

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112066975N2

Enrollment

Registered

2011-12-27

Start date

2012-02-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis. Rheumatoid arthritis, unspecified

Interventions

Intervention 1: methylprednisolone 1gr/d IV for 3 days. Intervention 2: dexamethasone 120mg/d IV for 3 days.

Treatment - Drugs

methylprednisolone 1gr/d IV for 3 days

dexamethasone 120mg/d IV for 3 days

Eligibility

Sex/Gender

All

Age

16 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: DAS28>5.2 Exclusion criteria: Congestive heart failure; active infection; hypokalemia (K+180 or diastolic BP>100; diabetes; pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Disease activity. Timepoint: 1 month. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Complications of treatment. Timepoint: daily for 3 days. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026