Effect of ephedrine to counteract hemodynamic changes following induction of anesthesia

Preventive effect of ephedrine to counteract hemodynamic changes following induction of anesthesia with propofol and remifentanil

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112061566N3

Enrollment

143

Registered

2012-01-31

Start date

2011-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypotension and heart rate fluctuation resulting from anesthesia induction.

Interventions

Intervention 1: Case group 1: Besides normal anesthesia induction drugs, ephedrine 0.07mg/kg was infused by a 2cc syringe. Intervention 2: Case group 2: Besides normal anesthesia induction drugs, ephe

Prevention

Placebo

Case group 1: Besides normal anesthesia induction drugs, ephedrine 0.07mg/kg was infused by a 2cc syringe

Case group 2: Besides normal anesthesia induction drugs, ephedrine 0.15mg/kg was infused by a 2cc syringe

Control group: Besides normal anesthesia induction drugs, distilled water was infused by a 2cc syringe as placebo

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria: 1) history of hypertension, angina pectoris, heart failure, thyrotoxicosis, gastrointestinal reflux, and cerebrovascular disease, 2) Use of muscle relaxants during operation, 3)history of using anti-hypertensive or cardiac related drugs, 4) hypersensitivity to eggs, 5) hypersensitivity to soya bean, 6) patient's dissatisfaction at any time. Inclusion criteria:1)age range of 20-50 years, 2)ASA I & II, 3)weight of 60-80 kg, 4) candidate for short-term operations under general anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hypotension resulting from anesthesia induction. Timepoint: Before intervention, 2 minutes after anesthesia induction, 1 and 5 minutes after tracheal intubation. Method of measurement: Operating room monitor.;Heart rate fluctuation resulting from anesthesia induction. Timepoint: Before intervention, 2 minutes after anesthesia induction, 1 and 5 minutes after tracheal intubation. Method of measurement: Operating room monitor.	—

Measure

Time frame

Hypotension resulting from anesthesia induction. Timepoint: Before intervention, 2 minutes after anesthesia induction, 1 and 5 minutes after tracheal intubation. Method of measurement: Operating room monitor.;Heart rate fluctuation resulting from anesthesia induction. Timepoint: Before intervention, 2 minutes after anesthesia induction, 1 and 5 minutes after tracheal intubation. Method of measurement: Operating room monitor.

—

Secondary

Measure	Time frame
Cardiac arythmia resulting from anesthesia induction. Timepoint: Continuous monitoring from the patients' interance to the operating room until five minutes after tracheal intubation. Method of measurement: Operating room monitor.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Hosseinipour

Shiraz University of Medical Sciences

hoseinipur@sums.ac.ir; alihoseinpour@gmail.com+98 71 1832 3519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026