Dexamethasone effect on oral glucose tolerance test

Effect of dexamethasone on glucose homeostasis in normal and prediabetic individuals with a first-degree relative with type 2 diabetes

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111308258N1

Enrollment

Registered

2011-12-26

Start date

2010-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus. Diabetes mellitus

Interventions

Intervention 1: A single oral 8 mg placebo tablet one time First day. Intervention 2: A single oral 8 mg dexamethasone tablet one time first day.

Placebo

A single oral 8 mg placebo tablet one time First day

A single oral 8 mg dexamethasone tablet one time first day

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:20-65 years old individuals with first degree relative of diabetic patients Exclusion criteria: Active peptic ulcer? active herpetic corneal ulcer? psychosis? positive pregnancy test? current use of oral contraceptives in women and thiazide or glucocorticoids use in any person

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Plasma insulin in 0,30,60,120 minutes during OGTT. Timepoint: first day and second day. Method of measurement: pmol/l.;Plasma glucose in 0,30,60,120 minutes durig OGTT. Timepoint: first day and second day. Method of measurement: mmol/l.	—

Secondary

Measure	Time frame
AUC(g)=Area under the curve of glucose. Timepoint: first day and second day. Method of measurement: By related formulae.;AUC(i)= Area under the curve of insulin. Timepoint: first day and second day. Method of measurement: By related formulae.;AUC(i) / AUC(g). Timepoint: first day and second day. Method of measurement: By related formulae.;HOMA-IR index. Timepoint: first day and second day. Method of measurement: By related formula.;Homa-B index. Timepoint: first day and second day. Method of measurement: By related formulae.;Matsuda index. Timepoint: first day and second day. Method of measurement: By related formulae.;Insulinogenic index. Timepoint: first day and second day. Method of measurement: By related formulae.;Disposition index. Timepoint: first day and second day. Method of measurement: By related formulae.	—

Measure

Time frame

AUC(g)=Area under the curve of glucose. Timepoint: first day and second day. Method of measurement: By related formulae.;AUC(i)= Area under the curve of insulin. Timepoint: first day and second day. Method of measurement: By related formulae.;AUC(i) / AUC(g). Timepoint: first day and second day. Method of measurement: By related formulae.;HOMA-IR index. Timepoint: first day and second day. Method of measurement: By related formula.;Homa-B index. Timepoint: first day and second day. Method of measurement: By related formulae.;Matsuda index. Timepoint: first day and second day. Method of measurement: By related formulae.;Insulinogenic index. Timepoint: first day and second day. Method of measurement: By related formulae.;Disposition index. Timepoint: first day and second day. Method of measurement: By related formulae.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Massoud Amini

Isfahan Endocrine and metabolism research center

emrc@mui.ac.ir+98 31 1335 9933

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026