Evaluation of pain in orthodontic patients

Evaluation of pain and inflammatory factors in the gingival lining fluid in orthodontic treatment with NITI and CUNITI wires

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111130008257N2

Enrollment

Registered

2018-01-03

Start date

2017-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Pain. Condition 2: Interleukin 21. Condition 3: Interleukin 6. Condition 4: Interleukin 17F. Condition 5: Interleukin 17A.

Interventions

Intervention 1: Intervention group: CuNiTi orthodontic wire, produced by Ormco, single application during study. Intervention 2: Intervention group: NiTi orthodontic wire, produced by American orthodo

Treatment - Devices

Treatment - Drugs

Intervention group: CuNiTi orthodontic wire, produced by Ormco, single application during study

Intervention group: NiTi orthodontic wire, produced by American orthodontics, single application during study

Eligibility

Sex/Gender

All

Age

12 Years to 25 Years

Inclusion criteria

Inclusion criteria: Good general and periodontal health Good oral hygiene Orthodontic treatment plan must not include tooth extraction Age: 12-25 years old Crowding in the anterior mandibular segment.

Exclusion criteria

Exclusion criteria: Chronic NSAID intake Presence of block outed tooth that does not allow the bracket to be placed in the initial bonding session Pregnancy Use of anti-inflammatory drugs in the month before the study Antibiotic therapy in the past 6 months Any previous orthodontic treatment Radiographic evidence of periodontal bone loss Spacing between the teeth in anterior segment of mandible

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Pain assessment will be done before wire insertion,1 hour,12 hours,24 hours,48 hours,7 days and 14 days after wire insertion. Method of measurement: questionnaire.;Interleukin 21. Timepoint: Interleukin 21 will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 6. Timepoint: Interleukin 6 will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 17F. Timepoint: Interleukin 17F will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 17A. Timepoint: Interleukin 17A will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.	—

Measure

Time frame

Pain. Timepoint: Pain assessment will be done before wire insertion,1 hour,12 hours,24 hours,48 hours,7 days and 14 days after wire insertion. Method of measurement: questionnaire.;Interleukin 21. Timepoint: Interleukin 21 will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 6. Timepoint: Interleukin 6 will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 17F. Timepoint: Interleukin 17F will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 17A. Timepoint: Interleukin 17A will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Bagheri

Shiraz University of Medical Sciences

mohsenbri@yahoo.com+98 71 3839 0327

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026