depression. Depressive episode
Conditions
Interventions
Intervention 1: Intervention group: sertraline 50 to 200mg orally per day. Intervention 2: Control group: Placebo 50 to 200 mg orally per day.
Treatment - Drugs
Placebo
Intervention group: sertraline 50 to 200mg orally per day
Control group: Placebo 50 to 200 mg orally per day
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1- Age between 18 to 80 years; 2- start to Haemodialysis of at least 3 months duration; 3- Receiving maintenance haemodialysis, 4 hour three times per week via a low flux polysulphone dialyser using bicarbonate dialysis fluid; 4- presence of depression based on Beck Depression Inventory (BDI). Exclusion criteria : 1- Patients with major acute infections, autoimmune disease, cancer, severe mental illness, cognitive dysfunction; 2- taking immunosuppressive agents like corticoestroieds for at least 1 month; 3- taking antiinflammatory drugs such as NSAIDs 3-Current use of an antidepressant medication; 4-Intolerance of Sertraline adverse effects.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: Baseline, 6 and 12 weeks after. Method of measurement: Beck Depression Inventory (BDI). | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation stutus. Timepoint: Baseline, 6 and 12 weeks after. Method of measurement: Inflammatory Cytokines (TNF-a, IL-6, IL-10, hs-CRP). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Taraz
Tehran University of Medical Sciences
Outcome results
None listed