Comparison of weight loss diets on long-term consequences of fatty liver disease in patients referred to the clinic Motahari Shiraz, 1390

A comparative study of the effect of low calorie balanced diet versus low calorie high fiber diet on the hepatic transaminases, lipid profiles, insulin, glucose levels, blood pressure and anthropometric measurements of obese patients with nonalcoholic fatty liver disease(NAFLD)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111218145N1

Enrollment

Registered

2012-02-16

Start date

2011-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver disease. Nonalcoholic steatohepatitis

Interventions

Intervention 1: Receive a balanced low-calorie high-fiber diet for 3 months (reduction of 700 kcal daily intake and received more than 15 grams of fiber per 1,000 kcal according to the definition of h

Lifestyle

Receive a balanced low-calorie high-fiber diet for 3 months (reduction of 700 kcal daily intake and received more than 15 grams of fiber per 1,000 kcal according to the definition of high-fiber diet(

Receive a balanced low-calorie diet for 3 months (reduction of 700 kcal daily intake and get as much as 14 grams of fiber per 1000 kcal intake according to the definition of balanced diet)

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 20-60; BMI>25; ALT>43 Exclusion criteria: Alcohol consumption; Hepatitis B; C; Cytomegalovirus; Epstein Barr infections; nonorgan-specific autoantibody hereditary defects (iron storage disease and copper; alpha-1 anti-trypsin deficiency)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
ALT. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.;AST. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.;GGT. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.;Bilirubin total. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.	—

Measure

Time frame

ALT. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.;AST. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.;GGT. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.;Bilirubin total. Timepoint: Before and 3 months after intervention. Method of measurement: Colorimetric method.

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Secondary

Measure	Time frame
Insulin. Timepoint: Before and 3 months after intervention. Method of measurement: ELISA kit.;Lipid profile. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyzer.;FBS. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyzer.;Body fat mass. Timepoint: Before and 3 months after intervention. Method of measurement: Body Composition Analyzer - Quad Scan 4000.;Blood pressure. Timepoint: Before and 3 months after intervention. Method of measurement: Mercury Barometer.;Weight. Timepoint: Before and 3 months after intervention. Method of measurement: Seca Scale.;Height, waist hip circumference. Timepoint: Before and 3 months after intervention. Method of measurement: Tape Meter.	—

Measure

Time frame

Insulin. Timepoint: Before and 3 months after intervention. Method of measurement: ELISA kit.;Lipid profile. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyzer.;FBS. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyzer.;Body fat mass. Timepoint: Before and 3 months after intervention. Method of measurement: Body Composition Analyzer - Quad Scan 4000.;Blood pressure. Timepoint: Before and 3 months after intervention. Method of measurement: Mercury Barometer.;Weight. Timepoint: Before and 3 months after intervention. Method of measurement: Seca Scale.;Height, waist hip circumference. Timepoint: Before and 3 months after intervention. Method of measurement: Tape Meter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBayan Roohi

School of Health And Nutrition, Shiraz University of Medical Sciences

bayan.roohi@yahoo.com rouhib@sums.ac.ir+98 71 1725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026