Investigating the effects of intravenous laser therapy on the recovery process in patients with Acute Kidney Injury (AKI) using urinary NGAL

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111121008146N33

Enrollment

Registered

2020-11-18

Start date

2018-08-23

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury. Acute kidney failure

Interventions

Intervention 1: Control group: 7 sessions of sham laser treatment. Intervention 2: Intravenous laser treatment with red or infrared radiation (wavelength=600-1100 nm, power=2 mW, irradiation time=30 m

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with intra-renal acute kidney injury (AKI) due to ATN (including toxic and ischemic interstitial nephritis)

Exclusion criteria

Exclusion criteria: Patients with pre-renal and post-renal acute kidney failure Patients with glomerulonephritis Patients who need immunosuppressive drugs such as patients with Lupus Patients who had been taking Omega-3 and corticosteroids within the past month Pregnant patients Patients with photosensitivity Patients with malignancy

Design outcomes

Primary

Measure	Time frame
Urine Neutrophil gelatinase-associated lipocalin (NGAL). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Measuring the NGAL levels in urine samples.;Glomerular filtration rate (GFR). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Using the following equation: (140-age)×(weight)× (0.85 if female)/72×Cr.;24-hour urine output. Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Urine sample.;Blood urea nitrogen (BUN). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Blood sample.;Creatinine. Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Blood sample.	—

Measure

Time frame

Urine Neutrophil gelatinase-associated lipocalin (NGAL). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Measuring the NGAL levels in urine samples.;Glomerular filtration rate (GFR). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Using the following equation: (140-age)×(weight)× (0.85 if female)/72×Cr.;24-hour urine output. Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Urine sample.;Blood urea nitrogen (BUN). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Blood sample.;Creatinine. Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Blood sample.

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Secondary

Measure	Time frame
Patient's quality of life (mental and physical health). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: 36-Item Short Form Survey.;Biochemical profile (Calcium, Phosphor, potassium, and sodium levels in blood, complete blood count, fasting blood sugar, total glycerides, total cholesterol, LDL, HDL, AST, ALT, ALKP). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Patient's blood sample.	—

Measure

Time frame

Patient's quality of life (mental and physical health). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: 36-Item Short Form Survey.;Biochemical profile (Calcium, Phosphor, potassium, and sodium levels in blood, complete blood count, fasting blood sugar, total glycerides, total cholesterol, LDL, HDL, AST, ALT, ALKP). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Patient's blood sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSheida Malekian

Shahid Beheshti University of Medical Sciences

laser.cntr@yahoo.com+98 21 2274 9221

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026