Diseases of the circulatory system.
Conditions
Interventions
Intervention 1: Control group: The placebo group (250 mg neutral micro cellulose capsules) will be given half an hour before sleep, and all the tests including heart function, and blood sampling, wil
Sponsors
Boushehr University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Intention of the patients to participate in the trial Patients on coronary artery bypass graft surgery Having no addiction to any drugs or alcohol Not having mental or psychological disorders Participants with the age between 30 to 70 years Absence of chronic diseases such as kidney, liver, digestive, bone diseases
Exclusion criteria
Exclusion criteria: The patient's refusal to continue cooperation after a period of taking the intervention The presence of special conditions after the operation, for example, the patient being unconscious and not being able to take the intervention The occurrence of any problems related to surgery, such as heart attack, cardiac arrhythmia, bleeding at the surgical site, myocardial damage, etc., which causes the patient's condition to become unstable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Antioxidant Capacity (TAC). Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By ELISA technique.;Malondialdehyde. Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By reliable kits (By using spectrophotometry).;Troponin T. Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By ELISA technique.;The heart function. Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By echocardiography.;Diastolic blood pressure. Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By sphygmomanometer, Mercury Type (Company: Microlife).;Systolic blood pressure. Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By sphygmomanometer, Mercury Type (Company: Microlife).;CK-MB (creatine kinase MB). Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By reliable kits (By using spectrophotometry).;LDH (lactate dehydrogenase). Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (60 days). Method of measurement: By reliable kits (By using spectrophotometry).;TNF-a (tumor necrosis factor-a). Timepoint: Around 24 hours, before the start of melatonin consumption, and 12 to 24 hours after the period of melatonin consumption (6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Alanine aminotransferase (ALT). Timepoint: Around 24 hours, before the start of melatonin consumption, and 24 to 72 hours after the period of 60 days of melatonin consumption. Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Aspartate aminotransferase (AST). Timepoint: Around 24 hours, before the start of melatonin consumption, and 24 to 72 hours after the period of 60 days of melatonin consumption. Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Alkaline phosphatase (ALP). Timepoint: Around 24 hours before the start of melatonin consumption, and 24 to 72 hours after the period of melatonin consumption(60 days) . Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Blood Urea Nitrogen. Timepoint: Around 24 hours before the start of melatonin consumption, and 24 to 72 hours after the period of melatonin consumption(60 days). Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Creatinine (Cr). Timepoint: Around 24 hours before the start of melatonin consumption, and 24 to 72 hours after the period of melatonin consumption(60 days). Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Low density lipids (LDL). Timepoint: Around 24 hours before the start of melatonin consumption, and 24 to 72 hours after the period of melatonin consumption(60 days). Method of measurement: By biochemistry auto analyzer- spectrophotometer.;High density lipid (HDL). Timepoint: Around 24 hours before the start of melatonin consumption, and 24 to 72 hours after the period of melatonin consumption(60 days). Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Cholesterol. Timepoint: Around 24 hours before the start of melatonin consumption, and 24 to 72 hours after the period of melatonin consumption(60 days). Method of measurement: By biochemistry auto analyzer- spectrophotometer.;Triglyceride (TG). Timepoint: Around 24 hours before the start of melatonin consump | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Movahed
Boushehr University of Medical Sciences
Outcome results
None listed