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Effect of sertraline on semen parameters in men with premature ejaculation

Effect of sertraline on semen parameters in men with premature ejaculation

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201111178121N1
Enrollment
60
Registered
2011-12-11
Start date
2012-01-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

premature ejaculation. Premature ejaculation

Interventions

Intervention 1: Control group: teaching squeeze, start-stop techniques in 0, 4th, 8th, 12th week after treatment. Intervention 2: Intervention group: tab sertraline 25mg/day, increasing dose to 50 mg/
Treatment - Drugs
Control group: teaching squeeze, start-stop techniques in 0, 4th, 8th, 12th week after treatment.
Intervention group: tab sertraline 25mg/day, increasing dose to 50 mg/day in first week for 3 months.

Sponsors

Vice chancellor for research, Kashan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age18-40; married men without any history of known sexual disorders; no cigarettes smoking or any drug abuse or alcohol consumption; BMI: 20-28. Exclusion criteria: drug holding because of severe adverse effects of sertraline or no suitable effects ( by patient ); loss of patients; patient with current or past history of psychological disorders like depression or chemotherapy or radiotherapy; patient with current or past history of seizure or clinical varichocele ; patient with current or past history of chronic disease like diabetes, cirrhosis, uremia,..; desire to have a child in time of study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Premature ejaculation. Timepoint: 0, 2nd week and 1st, 2nd, 3rd month after treatment. Method of measurement: self reporting questionnaire.;Sperm count. Timepoint: first visit and 3 weeks after that/3 months after treatment and 3 weeks after Completion of treatment. Method of measurement: spermogram.

Secondary

MeasureTime frame
Drug advers effects. Timepoint: 4th, 8th, 12th week. Method of measurement: self reporting.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Leila Sirati

Kashan University of Medical Sciences

sirati_L@kaums.ac.ir , daesmaili@gmail.com0O983614443023

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026