brain trauma. Diffuse brain injury
Conditions
Interventions
Intervention 1: initial intravenous loading dose of 50mg/kg magnesium sulfate within one hour after trauma and then 50mg/kg every 6 hour magnesium sulfate up to 24 hours after trauma. Intervention 2:
Treatment - Drugs
Placebo
initial intravenous loading dose of 50mg/kg magnesium sulfate within one hour after trauma and then 50mg/kg every 6 hour magnesium sulfate up to 24 hours after trauma
intravenous normal saline with the same dose of drug intervention
Sponsors
Deputy for Research,Faculty of Medicine.Tabriz University of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Older than 18 and less than 65 years old; the time gap between trauma and admission to the medical center not exceeding more than one hour Exclusion criteria: renal failure; pregnancy; seizure; cardiac heart failure;cranial hematoma; intracranial surgery for hematoma; refractory systemic hemorrhage requiring blood product transfusion; intracranial hemorrhage
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glascow coma scale (GCS). Timepoint: with in 2 month after trauma. Method of measurement: According to GCS score table.;Motot function. Timepoint: 2 month after trauma. Method of measurement: according to evaluating muscle force. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effect of magnesium sulfate. Timepoint: within 24 hours after magnesium sulfate administration. Method of measurement: yes or no. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactYazdan Dokhte Gafari M
Tabriz University of Medical Science
Outcome results
None listed