The impact of subcutaneous infiltration of 0.5% bupivacaien on the c-reactive protein titer and hemodynamic parameters after craniotomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111138087N1

Enrollment

Registered

2011-12-01

Start date

2011-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Craniotomy.

Interventions

Intervention 1: Subcutaneous injection of 20 ml o.9% normal saline. Intervention 2: Subcutaneous Injection of Bupivacaien 25%.

Placebo

Treatment - Drugs

Subcutaneous injection of 20 ml o.9% normal saline

Subcutaneous Injection of Bupivacaien 25%

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:being candidate for craniotomy and age between18 to 65 years. Exclusion criteria: need for emergency surgery ; previous craniotomy and Diabetes Melitus

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: Before, 1,5,10 and15 minuts after surgery. Method of measurement: Objective Record.;C-reactive protine. Timepoint: Before surgery, 24 and 48 Hours after surgery. Method of measurement: Plasma Sample.;Mean Arterial Pressure. Timepoint: Before, 1, 5,10 and 15 minuts after surgery. Method of measurement: Objective Record.	—

Secondary

Measure	Time frame
Tachycardia. Timepoint: Before suegery, 1; 5 10 and 15 minuts after surgery. Method of measurement: Obgective Recorde.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaber Aminzadeh

Tehran University of Medical Sciences

AMINZADEH@RAZI.TUMS.AC.IR+98 83 2722 7544

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026