Knee osteoarthritis. Primary gonarthrosis, bilateral
Conditions
Interventions
Intervention 1: The drug is extracted from ginger and packed as gelatinous capsule. Each capsule contains 1 gram of ginger extract that equal to 3 gram of crude plant. The patient must be taken 3 caps
Treatment - Drugs
The drug is extracted from ginger and packed as gelatinous capsule. Each capsule contains 1 gram of ginger extract that equal to 3 gram of crude plant. The patient must be taken 3 capsules by meal in
The placebo is made from same capsule but is filled by starch.
Sponsors
Tehran University of medical sciences, Vice chancellor for research
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria; knee pain and osteophyte in knee radiography; and at least one criterion of the three following criteria: 50 years age; Morning stiffness of less than 30 minutes; Crepitus in motion. Exclusion criteria: The history of rheumatoid arthritis, gout, chondrocalcinosis; severe and advanced cardiovascular disease class 4; proven malignancy; there is significant liver disease (esophageal varices and bleeding, encephalopathy, ascites); severe renal disease (creatinine greater than 3 mg dL); pregnancy and lactation; received intra-articular drug in former three months (or wait until this time period be spent); Glucosamine or Piascledine receive more than 2 weeks during the past six months; concomitant hip osteoarthritis
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee pain. Timepoint: 6 week. Method of measurement: VAS, Lequensnes Pain Index Of Severity For OA Of The Knee, VOMAC. | — |
Secondary
| Measure | Time frame |
|---|---|
| Joint crepitus. Timepoint: 6 month. Method of measurement: physical exam.;Patient global assessment. Timepoint: Each 6 weeks. Method of measurement: Interview.;Physician global assessment. Timepoint: Each 6 weeks. Method of measurement: Questionnaire.;Drug side effect. Timepoint: Each 6 weeks. Method of measurement: Interview. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Ahmad Salimzadeh
Tehran University of medical sciences, Sina Hospital
Outcome results
None listed