effect of probiotics on function of immune system in obesity

the effects of probiotic yogurt and regular one on balance of Tcells in obese and overwight persons : double blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111082709N21

Enrollment

Registered

2011-12-20

Start date

2011-09-17

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

overweight and obesity. Obesity due to excess calories

Interventions

Intervention 1: 25 overwieght and obese persons with weight reduction and cunsumption of probiotic yogurt with lactobacilus acidophillus La5 and lactobacilus casei DN001 and bifidobacter bb12. In

Prevention

Placebo

25 overwieght and obese persons with weight reduction and cunsumption of probiotic yogurt with lactobacilus acidophillus La5 and lactobacilus casei DN001 and bifidobacter bb12

25 overwieght and obese persons with weight reduction and cunsumption of regular yogurt with lactobacilus bulgaricus and Streptococcus thermophilus

25 overwieght and obese persons without weight reduction and cunsumption of probiotic yogurt with lactobacilus acidophillus La5 and lactobacilus casei DN001 and bifidobacter bb12

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: age of 20-50;BMI= 25-35;interesting in participation in research; without any metabolic disease , CHD, diabetes , without autoimmune disease , cancer; without infection disease in research ;without allergy for cow s milk; no smoking ; no alcoholism; without immune system suppressor drugs 6 mounts before research; no menstrual bleeding ;without any diet 2 mounts before research ;no consumption food supplementation during research exclusion criteria: metabolic disease , CHD, diabetes , autoimmune disease , cancer; infection disease in research ; allergy for cow s milk; smoking ; alcoholism; immune system suppressor drugs 6 mounts before research; menstrual bleeding; diet 2 mounts before research; lactose deficiency; food supplementation during research; no interesting for participation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Fat percent. Timepoint: after and before of intervention. Method of measurement: BIA method.;BMI. Timepoint: after and before of intervention. Method of measurement: fomula.;IL4-IL9-IL10- IL17- TNF alpha - IFN gama- TGF beta. Timepoint: after and before of intervention. Method of measurement: ELIZA.;Transcription factor of Foxp3 - TGF beta - TNF alpha - GATA3- t-bet -ROR gama IN PBMC. Timepoint: after and before of intervention. Method of measurement: real time- PCR.;Leptin. Timepoint: after and before of intervention. Method of measurement: ELIZA.;HsCRP. Timepoint: after and before of intervention. Method of measurement: ELIZA.	—

Measure

Time frame

Fat percent. Timepoint: after and before of intervention. Method of measurement: BIA method.;BMI. Timepoint: after and before of intervention. Method of measurement: fomula.;IL4-IL9-IL10- IL17- TNF alpha - IFN gama- TGF beta. Timepoint: after and before of intervention. Method of measurement: ELIZA.;Transcription factor of Foxp3 - TGF beta - TNF alpha - GATA3- t-bet -ROR gama IN PBMC. Timepoint: after and before of intervention. Method of measurement: real time- PCR.;Leptin. Timepoint: after and before of intervention. Method of measurement: ELIZA.;HsCRP. Timepoint: after and before of intervention. Method of measurement: ELIZA.

—

Secondary

Measure	Time frame
Waist circumference. Timepoint: after and before of intervention. Method of measurement: meter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactdr. farzad shidfar

School of Public Health , Tehran University of Medical Science

farzadshidfar@yahoo.com+98 21 8877 9118

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026