The effect of thoracic epidural combined with total intravenous anesthesia on dose requirement for induction of anesthesia & bis pectoral index

The effect of low thoracic epidural anesthesia combined with total intravenous anesthesia on dose requirement for induction and monitoring of depth of anesthesia guided by bispectoral index in patients under upper abdomen surgeries: randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111074731N9

Enrollment

Registered

2012-03-03

Start date

2011-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: BIS changes due to thoracic epidural anesthesia. Condition 2: anesthesia drug dose changes due to thoracic epidural. Other and unspecified effects of external causes Other and unspecified effects of external causes

Interventions

Intervention 1: Intervention group: after epidural catheter insertion marcaine 0.25%,0.7ml/m/seg for 10 segments will be adminstered. Intervention 2: Control group: after epidural catheter insertion

Placebo

Intervention group: after epidural catheter insertion marcaine 0.25%,0.7ml/m/seg for 10 segments will be adminstered

Control group: after epidural catheter insertion ,normal saline with same volume of marcaine will be adminstered

Eligibility

Sex/Gender

All

Age

18 Years to 149 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Adult patients, belonging to ASA 1&2 class; undergoing elective upper abdomen surgeries. Exclusion criteria: vertebral abnormality; neurologic disorders; cardio vascular diseases; Hgb <12; renal or hepatic failure; chest trauma; Allergy to local anesthetics; Plt <100000; Coagulopathy, ßblockers.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Oxygen Saturation. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: pulse oxymetry devices.;Mean arterial blood pressure. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: with automatic cuff.;BIS. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: BIS devices.;Propofol dose for induction & maintenance of anesthesia. Timepoint: Afer intubation, after extubation. Method of measurement: Infusion pump.;Heart rate. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: continuous ECG monitoring.	—

Measure

Time frame

Oxygen Saturation. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: pulse oxymetry devices.;Mean arterial blood pressure. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: with automatic cuff.;BIS. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: BIS devices.;Propofol dose for induction & maintenance of anesthesia. Timepoint: Afer intubation, after extubation. Method of measurement: Infusion pump.;Heart rate. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: continuous ECG monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamzeh Hosseinzadeh

Tabriz University of Medical Sciences

hamzeh1338@yahoo.com00894113855002

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026