Investigating of Silybum marianum fruit extract on MS fatigue

Study of effect of Silybum marianum fruit extract on fatigue in patients with multiple sclerosis: double blind, clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111105008013N8

Enrollment

Registered

2020-01-26

Start date

2020-01-10

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Multiple sclerosis. Condition 2: Neurasthenia. Multiple sclerosis Neurasthenia

Interventions

Intervention 1: Intervention group: Interferon (main treatment) with Milk thistle capsules (420 mg daily) for one month. Intervention 2: Control group: Interferon (main treatment) with placebo capsul

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Multiple sclerosis patients have fatigue Ages between 15-65 years old

Exclusion criteria

Exclusion criteria: other neurological disease Diseases like diabetes and autoimmune diseases new attack in the last month New disease attack Pregnancy

Design outcomes

Primary

Measure	Time frame
Fatigue. Timepoint: Start intervention and a month later. Method of measurement: MFIS questionnaire.;Quality of Life. Timepoint: Start intervention and a month later. Method of measurement: MSQL-54 questionnaire.	—

Secondary

Measure	Time frame
Side effects. Timepoint: One month after the intervention began. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Siahpoosh

Ahvaz University of Medical Sciences

Amirsiahpoosh@yahoo.com+98 61 3334 2197

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026