The effect of nortriptiline on nocturnal enuresis

The effect of nortriptiline on nocturnal enuresis in children and adolescents with attention deficit hyperactivity disorder

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111043930N16

Enrollment

Registered

2012-03-21

Start date

2011-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enuresis. Nonorganic enuresis

Interventions

Intervention 1: Methylphenidate + Nortriptline (25-50 mg/day). Intervention 2: Methylphenidate + Placebo.

Treatment - Drugs

Placebo

Methylphenidate + Nortriptline (25-50 mg/day)

Methylphenidate + Placebo

Eligibility

Sex/Gender

All

Age

5 Years to 17 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: meeting diagnostic criteria for current ADHD and primary enuresis according to DSM-IV-TR; aged 5 to 14 years; both genders; and providing written consent. Exclusion criteria: any major psychosocial stressors; urinary complaints; and co-current behavior therapy for enuresis.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Frequency of enuresis. Timepoint: every 2 weeks. Method of measurement: parent report.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026