Vitamin B6 in the treatment of akathisia

Effect of Vitamin B6 versus propranolol in patients with neuroleptic -induced Akathisia : ?A randomized-double blind study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201111042935N6

Enrollment

Registered

2012-02-18

Start date

2012-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

medication-induced acute akathisia. Other extrapyramidal and movement disorders

Interventions

Intervention 1: vitamin B6 600 mg per day for 5 days. Intervention 2: vitamin B6 1200 mg per day for 5 days. Intervention 3: propranolol 40 mg per day for 5 days.

Treatment - Drugs

vitamin B6 600 mg per day for 5 days

vitamin B6 1200 mg per day for 5 days

propranolol 40 mg per day for 5 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria:being hospitalized ;receiving neuroleptic medication; Presence of akathisia based on DSM-IV criteria; Baseline Barnes Akathisia Scale (BAS) score of at least 2 Exclusion criteria: any hepatic or renal disease; change in the dose of anticholinergic drugs within 5 days before the trial; receiving any beta-blocker medication during the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of akathisia. Timepoint: baseline and every day up to 5 days. Method of measurement: Barnes Akathisia Scale (BAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Narges Shams Alizadeh

Kurdistan University of Medical Sciences

nshamsalizadeh@yahoo.com+98 87 1666 0025

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026