The local effect of two antidepressant drugs on pain reduction in teeth with severe tooth ache ( irreversible tooth pulp inflammation) during root canal therapy.

The effect of Amitriptyline and Imipramyne on pain reduction in teeth with irreversible pulpitis while preparing access cavity.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201110317963N1

Enrollment

Registered

2012-04-01

Start date

2012-04-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis. Diseases of pulp and periapical tissues-Pulpitis-irreversible

Interventions

Intervention 1: 0.2 ml Amitriptyline + propylen glycole ( 1mg/ml) is applyed locally on the carious dentin of the tooth and after 5 minutes its effect on the patients pain is assessed. Inte

Treatment - Drugs

Placebo

0.2 ml Amitriptyline + propylen glycole ( 1mg/ml) is applyed locally on the carious dentin of the tooth and after 5 minutes its effect on the patients pain is assessed

0.2 ml Imipramyne + propylen glycole ( 1mg/ml) is applyed locally on the carious dentin of the tooth and after 5 minutes its effect on the patients pain is assessed

0.2 ml propylen glycole is applyed locally on the carious dentin of the tooth and after 5 minutes its placebo effect on the patients pain is assessed

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patient ( male or female )with a molar tooth with a pulpal and periapical diagnosis of symptomatic irreversible pulpitis; healthy patient with a non-contributory medical history; patient must not use any medicaments; must not have any allergy to the drugs used in this experiment or other tricyclic antidepressant; must not use tricyclic antidepressant; after administration of local anesthetic must still experience pain during the preparation of the access cavity. exclusion criteria: patient ( male or female ) with any systemic disease; patient using any medicament; patient with allergy to the drugs used in this experiment or other tricyclic antidepressant; use of tricyclic antidepressant; after administration of local anesthetic does experience pain during the preparation of the access cavity.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 5 minute after application of the drug. Method of measurement: VAS scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Aminsobhani

Dental Faculty of Tehran University of Medical Sciences

maminsobhani@irimc.org maminsobhani@yahoo.com+98 21 8835 1173

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026