comparison of ketamine, Doxapram and mepredine in preventing post anesthesia shivering

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201110254923N3

Enrollment

120

Registered

2011-11-15

Start date

2011-09-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of shaking after general anesthesia. Other specified complications of surgical and medical care, not elsewhere classified

Interventions

Intervention 1: Intervention group: Amp Ketamine 20mg IV, 10 min before the end of the surgery. Intervention 2: Intervention group: Amp Doxaperam 1.5mg/kg IV, 10min before the end of the surgery. Inte

Prevention

Intervention group: Amp Ketamine 20mg IV, 10 min before the end of the surgery

Intervention group: Amp Doxaperam 1.5mg/kg IV, 10min before the end of the surgery

Control group: Amp Meperidine 20mg IV, 10min before the end of the surgery

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 18-60 years old, ASA Class I-II, candidate for general anesthesia Exclusion criteria: presence of underlying disease such as epilepsy, allergy, CHF, Need for transfusion, duration of operation more than 1.5 h, Laparascopic or endoscopic procedure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Shivering. Timepoint: After entering the recovery in minutes 1,5,10,15,30,60. Method of measurement: Visual-0:without shivering , I:Mild fasciculation in head & neck . II: Tremor in more than one muscle III: Generalized movement in extremities.	—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: Before & after intubation, Before & 5min after drug administration , before & after Extubation & in recovery minute 1,5,10,15,30,60. Method of measurement: BP Cuff.;Temprature. Timepoint: Before & after intubation& every 15 minutes until the end of the surgery , the time of entering recovery & minute 15,30,45,60. Method of measurement: Measurement with Axillary prob & oropharyngial prob connected to the monitoring device.;Hear rate. Timepoint: Before & after intubation, before & 5min after drug administration, before & after Extubation & in recovery minute 1,5,10,15,30,60. Method of measurement: ECG,Pulse Oximeter.;Nausea & Vomiting. Timepoint: Recovery in minute 1,5,10,15,30,60. Method of measurement: question & observation.	—

Measure

Time frame

Blood Pressure. Timepoint: Before & after intubation, Before & 5min after drug administration , before & after Extubation & in recovery minute 1,5,10,15,30,60. Method of measurement: BP Cuff.;Temprature. Timepoint: Before & after intubation& every 15 minutes until the end of the surgery , the time of entering recovery & minute 15,30,45,60. Method of measurement: Measurement with Axillary prob & oropharyngial prob connected to the monitoring device.;Hear rate. Timepoint: Before & after intubation, before & 5min after drug administration, before & after Extubation & in recovery minute 1,5,10,15,30,60. Method of measurement: ECG,Pulse Oximeter.;Nausea & Vomiting. Timepoint: Recovery in minute 1,5,10,15,30,60. Method of measurement: question & observation.

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026