Effect of Ozone injection on knee osteoarthritis

Effect of intra-articular Ozone injection on pain and function in patients with mild to moderate knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111025007903N13

Enrollment

Registered

2023-05-11

Start date

2020-01-15

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: For knee injection, a 22-gauge syringe was used by the classic anterolateral approach in a supine position and at an angle of 90 degrees to the knee. In the interve

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: Mild to moderate knee osteoarthritis Body mass index less than 30 Pain exacerbation with walking Age between 45 and 75 years

Exclusion criteria

Exclusion criteria: History of knee trauma or surgery, metabolic or autoimmune diseases Knee effusion Pregnancy or lactation Usage of anti-coagulant drugs

Design outcomes

Primary

Measure	Time frame
Knee pain. Timepoint: before intervention, 6 weeks and, 6 months after injection. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Function. Timepoint: before intervention, 6 weeks and, 6 months after injection. Method of measurement: 6minute walking test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Alizade

Tehran University of Medical Sciences

z_alizadeh@tums.ac.ir+98 21 6119 2282

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026