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Use of Montelucast in reducing the recurrence of steroid dependence nephrotic syndrome

Investigation of the effect of using Montelucast on reducing the recurrence of steroid dependence nephrotic syndrome

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20111024007892N9
Enrollment
10
Registered
2020-04-03
Start date
2019-10-09
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

frequently relapsing nephrotic syndrome with sensitivity to steroid. Nephrotic syndrome with minor glomerular abnormality

Interventions

Intervention 1: Intervention group: One 5-mg Montelucast pill (produced by Abidi-pharma company under Airokast brand name) is prescribed daily for one month with 1 mg/kg Prednisolone. Intervention 2:

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 15 Years

Inclusion criteria

Inclusion criteria: Patients with frequently relapsing nephrotic syndrome ( 4 times or more in a year) sensitivity to steroid ( proper response to treatment with oral Corticosteroid with dosage of 1-2 mg/kg in a patient)

Exclusion criteria

Exclusion criteria: extreme edema resistance to treatment with Corticosteroid

Design outcomes

Primary

MeasureTime frame
Ratio of urine protein to creatinine. Timepoint: before and one month after the beginning of treatment. Method of measurement: biochemical test.;Serum Albumin. Timepoint: before and one month after the beginning of treatment. Method of measurement: biochemical test.;Creatinine. Timepoint: before and one month after the beginning of treatment. Method of measurement: biochemical test.;Cholesterol. Timepoint: before and one month after the beginning of treatment. Method of measurement: investigation in laboratory.;Short term rate of recovery. Timepoint: one month after the beginning of treatment. Method of measurement: clinical observation.;Complications. Timepoint: one month after the beginning of treatment. Method of measurement: clinical observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Malaekeh

Mashhad University of Medical Sciences

malaekehns961@mums.ac.ir+98 51 3726 9021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026