Effect of oral calcitriol pulse therapy in comparison with oral daily calcitriol method in hemodiyalis paitients

Comparison the effect of oral calcitriol pulse therapy with oral daily calcitriol method in hemodiyalis paitients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111024007892N10

Enrollment

Registered

2022-04-12

Start date

2020-12-21

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Secondary hyperparathyroidism of renal origin. Secondary hyperparathyroidism of renal origin

Interventions

Intervention 1: Intervention group: Oral calcitriol pulse therapy (0.75 micro gram per kilogram), three times weekly. Intervention 2: Control group: Oral daily calcitriol (0.25 micro gram per kilogram

Eligibility

Sex/Gender

All

Age

1 Years to 18 Years

Inclusion criteria

Inclusion criteria: Patients with chronic kidney disease (CKD) who are under chronic hemodialysis and need to receive Calcitriol for secondary hyperparathyroidism Age less than 18 years Serum bicarbonate more than 15 mEq/L Serum albumin more than 3 g/dl Hemoglobin more than 8 g/dl

Exclusion criteria

Exclusion criteria: Primary metabolic disorder Intestinal malabsorption Endocrine or liver disease Malignancies Receiving corticosteroid Receiving rhGH Hypocalcemia or hypercalcemia hypophosphatemia or hyperphosphatemia

Design outcomes

Primary

Measure	Time frame
Serum level of calcium. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of phosphorous. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of vitamin D. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of alkaline phosphatase. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of parathormone. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.	—

Measure

Time frame

Serum level of calcium. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of phosphorous. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of vitamin D. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of alkaline phosphatase. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.;Serum level of parathormone. Timepoint: Baseline and one month after intervention. Method of measurement: laboratory measurement in blood sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAnoush Azarfar

Mashhad University of Medical Sciences

azarfara@mums.ac.ir+98 51 3726 9021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026