Major Depression. Severe depressive episode without psychotic symptoms
Conditions
Interventions
Intervention 1: Taking a Zinc sulfate capsule, 25 mg once a day for 12 weeks (intervention). Intervention 2: Taking a placebo capsule once a day for 12 weeks.
Treatment - Drugs
Placebo
Taking a Zinc sulfate capsule, 25 mg once a day for 12 weeks (intervention)
Taking a placebo capsule once a day for 12 weeks
Sponsors
Department of Clinical Nutrition and Diet therapy, Faculty of Nutrition Sciences and Food Technology
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: - A diagnosis of major depressive disorder - Have no current medical illness (diabetes, cancer, cardiovascular, inflammatory, liver or renal diseases) - No antepartum or postpartum depression - Current treatment with medication except for depressive disorder - Current use of multivitamin-mineral supplement Exclusion criteria: - pregnancy or lactation - any change in medication - A diagnosis of a new medical illness during study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: at the begining, after 6 and 12 weeks of supplementation. Method of measurement: Hamilton and Beck Depression Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma concentration of brain-derived growth factor. Timepoint: Before and after 12 weeks of treatment. Method of measurement: Biochemical assay.;Plasma concentration of Tumor Necrosis Factor-a. Timepoint: Before and after 12 weeks of treatment. Method of measurement: Biochemical assay.;Plasma concentration of Interleukin-6. Timepoint: Before and after 12 weeks of treatment. Method of measurement: Biochemical assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Ranjbar
Shahid Beheshti University of Medical Sciences
Outcome results
None listed