Condition 1: acute lymphoblastic leukemia. Condition 2: acute myeloid leukemia. Acute lymphoblastic leukaemia Acute myelblastic leukaemia
Conditions
Interventions
Intervention 1: For all participants in both groups, a prophylactic phase will be started from the first day of chemotherapy. In this phase standard oral hygiene will be recommended, furthermore chlor
Prevention
For all participants in both groups, a prophylactic phase will be started from the first day of chemotherapy. In this phase standard oral hygiene will be recommended, furthermore chlorhexidine 0.12%,
In intervation group, low level laser (660nm, 25 mw and 1.5 J/cm2) will be applied on 18 different points in the mouth, 2 times a week during chemotherapy.
Sponsors
Dental faculty, Shiraz university of medical sciences
Eligibility
Sex/Gender
All
Age
12 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 12-70 y/o; both genders; suffering acute myeloid/lymphoblastic leukemia; receiving myeloablative chemotherapy regimen; healthy oral mucosa at before starting chemotherapy; able to cooperation; filling the informed consent form. Exclusion criteria: unhealthy oral mucosa (erythema, ulcer, soreness) before starting chemotherapy; non ablative chemotherapy regimen; inability or unwillingness for being involved.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reducing the incidence of ulcer and erythema. Timepoint: 1 week, 2 weeks, 3 weeks, 4 weeks. Method of measurement: observation of the erythema and ulcer accordig to WHO & NCI scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reducing pain. Timepoint: 1 week, 2 weeks, 3 weeks, 4 weeks. Method of measurement: explaining the amount of pain according to the patients' expression (1-10 numbers). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Mohammad Mehdi Fani
Oral medicine department, Dental faculty
Outcome results
None listed