Skip to content

Effectiveness of PRP in treatment of Knee degenerative disorder

Comparison of functional improvement and quality of life in knee osteoarthritis after treatment of PRP (platelet rich plasma) and exercise: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201110117770N1
Enrollment
66
Registered
2013-01-18
Start date
2012-02-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Gonarthrosis [arthrosis of knee]

Interventions

Intervention 1: 5 cc of PRP injection in 4 weeks interval and knee isometric exercise (4 types) 3 times in day, 10 times every exercise. Intervention 2: knee isometric exercise (4 types) 3 times in da
Treatment - Drugs
Treatment - Other
5 cc of PRP injection in 4 weeks interval and knee isometric exercise (4 types) 3 times in day, 10 times every exercise
knee isometric exercise (4 types) 3 times in day, 10 times every exercise

Sponsors

Shahid Beheshti university of Medical siences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: history of chronic (at least 3months) pain or swelling of the knee and imaging ?ndings (X-ray or MRI) of degenerative changes of the joint according of American college of Rheumatology. Exclusion criteria: systemic disorders such as diabetes, rheumatoid arthritis, major axial deviation (varum 20 degree, valgum 20 degree), hematological diseases (coagulopathy), severe cardiovascular diseases, infections, immunodepression, patients in therapy with anticoagulants or antiaggregants, the use of NSAIDs in the 2 days before blood donation and patients with Hb values of 12 and platelet values of 150,000/mmc; Pregnancy; breast feeding; vasovagal shock; severe trauma; injection of corticosteroid in knee joint since 2 weeks ago.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Function. Timepoint: 6 months. Method of measurement: WOMAC Questianir.;Quality of life. Timepoint: 6 months. Method of measurement: SF36 questinair.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Babaee

Physical medicine and Rehabilitation department of Shahid Beheshti university of medical siences

rambabaee@yahoo.com+98 21 2273 1112

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026