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Effect of Mytomycin-C on the Corneal Endothelium

Effect of using mitomycin-c during Laser Assisted Sub-Epithelial Keratectomy on the corneal endothelium: A Clinical Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201110087741N1
Enrollment
100
Registered
2012-01-08
Start date
2010-11-06
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myopia. Visual disturbances and blindness

Interventions

Intervention 1: One eye was randomly assigned to receive intraoperative topical MMC, and Balanced Salt Solution (BSS) was used in control group. In each subject, MMC 0.02% (0.2 mg/ml) solution was app
Treatment - Drugs
One eye was randomly assigned to receive intraoperative topical MMC, and Balanced Salt Solution (BSS) was used in control group. In each subject, MMC 0.02% (0.2 mg/ml) solution was applied on the abla
In control group BSS was applied on the ablated zone.

Sponsors

Basir eye center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Myopic patients with ablation depths less than 65 µm. Exclusion criteria: Patients with unstable refraction, suspicion of keratoconus, excessive dry eyes, impaired wound healing processes, lenticular changes, corneal dystrophy, history of ocular surgery, anterior or posterior uveitis, glaucoma, and retinal diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Endothelial cell density. Timepoint: pre surgical and 3 and 6 months post surgical. Method of measurement: specular microscopy.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Aslani

Tehran University of Medical Sciences

md_aslani@yahoo.com+98 21 6659 2626

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026