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The comparison of eye side effects of Osferal and Deferoxamine in patients with major thalassemia

The comparative study of incidence of lens opacity between Osferal and Deferoxamine in major thalassemia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201110087677N1
Enrollment
50
Registered
2011-10-16
Start date
2010-12-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major thalassemia. Beta thalassaemia

Interventions

Intervention 1: Intervention:In this group, 25 patients are put on a new irainian drug e
Osferal, and then it's side effect that is "lens opacity", will be compared with that of the control group. Intervention 2: Control:Based on the present policy, 25 patients who receive Deferoxamine an
Treatment - Drugs
Intervention:In this group, 25 patients are put on a new irainian drug e
Osferal, and then it's side effect that is "lens opacity", will be compared with that of the control group.
Control:Based on the present policy, 25 patients who receive Deferoxamine and have a known percent of "lens opacity", are considered as the control group.

Sponsors

Vice chancellor for research Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 14 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: children having major thalassemia , being candidate for chelator therapy because of iron overload Exclusion criteria: diabetes mellitus and rheumatologic diseases, any lens disease or chelator therapy before the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Lens opacity. Timepoint: After one year. Method of measurement: Ophthalmologic examinations.

Secondary

MeasureTime frame
Age- Gender- Family history. Timepoint: One year. Method of measurement: Answer sheet.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahid Falahati

Imam Reza hospital, KUMS

vahidfalahati89@yahoo.com+98 83 1427 6333

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026