Acetylcysteine Infusion efficacy in patients with acute Acetamonophen poisoning l

Comparison of Treated with 12-Hour vs. 21-Hour Acetylcysteine Infusion in patients with acute poisoning due to acetaminophen referred to Isfahan Khorshid Hospital

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111003007710N2

Enrollment

Registered

2022-06-08

Start date

2022-04-21

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acetaminophen poisoning.

Interventions

Intervention 1: Intervention group: In this group, the treatment protocol with NAC is 100 mg / kg in 200 cc of 5% dextrose serum during the first hour and then 200 mg / kg in 1000 cc of 5% dextrose se

Eligibility

Sex/Gender

All

Age

13 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients who referred to the poisoned emergency room of Khorsid Hospital in Isfahan after poisoning with a toxic dose of acetaminophen

Exclusion criteria

Exclusion criteria: History of chronic liver and kidney disease History of cancer and chemotherapy Take high doses of corticosteroids Concomitant use of drugs other than acetaminophen in toxic doses Previous unnormal ECG

Design outcomes

Primary

Measure	Time frame
Blood Acetaminophen level. Timepoint: Upon arrival, two hours before the end of the protocol, 24 hours and one week after discharge. Method of measurement: HPLC.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasim Tavakoli

Esfahan University of Medical Sciences

Drnasimtavakoli@gmail.com+98 31 3222 2255

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026