obsessive compulsive disorder. Obsessive-compulsive disorder
Conditions
Interventions
Intervention 1: Intervention group: Clonidine tablets start with a dose of 0.1 mg once a night, and weekly (based on patient tolerance) 0.2 mg will add to reach a maximum of one mg per day. This dose
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The presence of obsessive-compulsive disorder criteria based on DSM-V-TR Receive at least 12 weeks with a maximum dose of a serotonergic drug (SSRI or Clomipramine) Moderate to severe symptoms based on the obsessive-compulsive- Yerobyll-Brown scale (YBOCS) with a score of more than 16 Obtain informed consent from the patient No initial diagnosis of psychiatric disorders and mood disorder (bipolar or MDD) Absence of drug use or dependence There is no uncontrolled physical illness (such as diabetes, blood pressure, etc.) There is no previous history of Clonidine use Lack of pregnancy and lactation or planning for pregnancy during the study There is no seizure disorder No suicide attempt Not taking beta-blocker Failure to receive synchronous psychological intervention
Exclusion criteria
Exclusion criteria: Cancellation of participation in the study at each stage of the research Pregnancy at each stage of the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OCD Scale changes with YBOCS questionnaire. Timepoint: Before the intervention and at the end of 4-8-12 weeks. Method of measurement: Yale Brown Obsessive-Compulsive Scale (YBOCS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahla Akuchekian
Esfahan University of Medical Sciences
Outcome results
None listed