heart failure. Left Ventricular Failure
Conditions
Interventions
Intervention 1: intervention group:
Melatonin tab 3 mg , 1 hour before night sleep for 2 months. Intervention 2: control group:cellulose tab 1 hour before night sleep for 2 months.
Treatment - Drugs
Placebo
intervention group:
Melatonin tab 3 mg , 1 hour before night sleep for 2 months
control group:cellulose tab 1 hour before night sleep for 2 months
Sponsors
Vice Chancellor For Research of Isfahan Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with heart failure NYHA (New York Heart Association) classes II, III; LVEF (Left Ventricular Ejection Fraction) less than 50 percent of which is determined by echocardiography; Stability for at least 3 months (at least in 3 last months there was no exacerbation or change in patient’s drugs). Exclusion criteria: Incidence of ecchymosis, petechiae, or any evidence of coagulation disorders; Detection of side effects such as gastrointestinal symptoms, drowsiness, mood changes.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EF (Ejection Fraction). Timepoint: Before and 2 months after intervention. Method of measurement: Echocardiography.;NYHA Functional class. Timepoint: Before and 2 months after intervention. Method of measurement: questionaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Kazem Alizadeh Noghani
Heart Department of Medical school, Isfahan university of medical sciences and health services
Outcome results
None listed