The effectiveness of ketamine spraying on postoperative throat problems in cesarean section under general anesthesia

The effectiveness of ketamine spraying on endotracheal tube cuff for reducing postoperative sore throat, cough, and hoarseness in cesarean section under general anesthesia .

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201109101951N2

Enrollment

120

Registered

2013-06-24

Start date

2013-01-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative sore throat, cough and hoarseness. Other postprocedural respiratory disorders

Interventions

Intervention 1: Ketamine group: 50 mg (1 ml) ketamine (ROTEXMEDICA, TRITTAU, GERMANY) will sprayed on the endotracheal tube cuff. Intervention 2: Normal saline (N) group: 1 ml normal saline will spr

Prevention

Ketamine group: 50 mg (1 ml) ketamine (ROTEXMEDICA, TRITTAU, GERMANY) will sprayed on the endotracheal tube cuff.

Normal saline (N) group: 1 ml normal saline will sprayed on the endotracheal tube cuff.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Term singleton pregnancies who were scheduled for elective cesarean delivery under general anesthesia . Exclusion criteria: A history of recent respiratory tract infection or sore throat, Asthma, Mallampati grade >2, Recent NSAID medication, Known allergies to study drug,Heart rate greater than 100/min, Weight >115 kg, Diabetes mellitus, Pregnancy-induced hypertension, Patients receiving steroid therapy, Those who required more than one attempt at intubation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative sore throat. Timepoint: At 1 and 6 and 24 hours after surgery. Method of measurement: By questionnaire based on scoring system.;Postoperative hoarseness. Timepoint: At 1 and 6 and 24 hours after surgery. Method of measurement: By questionnaire based on scoring system.;Postoperative cough. Timepoint: At 1 and 6 and 24 hours after surgery. Method of measurement: By questionnaire based on scoring system.	—

Measure

Time frame

Postoperative sore throat. Timepoint: At 1 and 6 and 24 hours after surgery. Method of measurement: By questionnaire based on scoring system.;Postoperative hoarseness. Timepoint: At 1 and 6 and 24 hours after surgery. Method of measurement: By questionnaire based on scoring system.;Postoperative cough. Timepoint: At 1 and 6 and 24 hours after surgery. Method of measurement: By questionnaire based on scoring system.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Nasrin Faridi Tazeh-kand

Arash Women 's Hospital , Tehran University of Medical Sciences

nfaridi@sina.tums.ac.ir+98 21 7771 9922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026