comparative study of three ovulation trigger methods in IVF/ICSI in poor response

Comparative study of double recombinant HCG injection and HCG injection (alone and in combination with GNRH) on the pregnancy outcome of patients with poor response in the ovulation stimulation cycle (IVF / ICSI)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110908007513N16

Enrollment

150

Registered

2022-04-16

Start date

2022-05-05

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female infertility

Interventions

Intervention group: Intervention group: in the control group for triggering the traditional HCG method with KARMA brand alone is given at a dose of 10,000 units. In the first intervention group HCG wi

Eligibility

Sex/Gender

Female

Age

30 Years to 43 Years

Inclusion criteria

Inclusion criteria: According to the Blogna (Bologna) criteria, people who meet the following two criteria are:1- Age over 40 years or risk factor to reduce ovarian reserve such as history of ovarian surgery, etc.2 - History of poor previous response to IVF (less than 3 oocytes in the previous cycle)Abnormal ovarian reserve test AFC (number of antral follicles) less than 5 to 7 or AMH (antimullerian hormone) less than 1/1

Exclusion criteria

Exclusion criteria: Patients who become infected with the coronavirus during the cycle, patients who do not respond well to the ovulation stimulation cycle and do not actually have a follicle to empty, patients who mistakenly take medication during the cycle.

Design outcomes

Primary

Measure	Time frame
Comparison of the mean number of oocytes obtained and the rate of positive pregnancy serum test, frequency of pregnancy sac viscosity on ultrasound, frequency of fetal heart rate on ultrasound, frequency of pregnancy continuity up to 12 weeks of pregnancy are used in the three study groups. Timepoint: The time of oocyte count after ovuum pickup and the time of positive pregnancy test 2 weeks after embryo transfer and the time of pregnancy sac evaluation week after embryo transfer and the time of implantation test 5 weeks after embryo transfer and the time of pregnancy test 12 weeks in 12 weeks of pregnancy. Method of measurement: Evaluation of oocyte count after ovum pickup under a microscope to evaluate pregnancy test with HCG beta titration blood test and examination of pregnancy and pregnancy bags at 12 weeks with ultrasound.	—

Measure

Time frame

Comparison of the mean number of oocytes obtained and the rate of positive pregnancy serum test, frequency of pregnancy sac viscosity on ultrasound, frequency of fetal heart rate on ultrasound, frequency of pregnancy continuity up to 12 weeks of pregnancy are used in the three study groups. Timepoint: The time of oocyte count after ovuum pickup and the time of positive pregnancy test 2 weeks after embryo transfer and the time of pregnancy sac evaluation week after embryo transfer and the time of implantation test 5 weeks after embryo transfer and the time of pregnancy test 12 weeks in 12 weeks of pregnancy. Method of measurement: Evaluation of oocyte count after ovum pickup under a microscope to evaluate pregnancy test with HCG beta titration blood test and examination of pregnancy and pregnancy bags at 12 weeks with ultrasound.

—

Secondary

Measure	Time frame
Nothing. Timepoint: nothing. Method of measurement: nothing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHatav Ghasemi Tehrani

Esfahan University of Medical Sciences

Tehrani@med.mui.ac.ir+98 913 113 4081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026