Effect of Mexiletine on depth of anesthesia

? Evaluation Of Mexiletine Effect On BIS Index Change &Hemodynamic Responses To Endotracheal Intubation &During General Anesthesia in upper limbs surgeries

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201109067488N1

Enrollment

Registered

2012-12-28

Start date

2012-04-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

B.I.Sindex,B.P,H.R. Injuries to upper extrimity

Interventions

Intervention 1: Case group: Mexiletine Cap 200 mg , 2hours before operation. Intervention 2: control group :Multivitamin Cap ,2hours before operation.

Treatment - Drugs

Case group: Mexiletine Cap 200 mg , 2hours before operation

control group :Multivitamin Cap ,2hours before operation

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria:Patients scheduled for upper limb orthopedic surgery under G.A with A.S.A 1,2,aged 20-60 yrs.Exclusion Criteria:Liver disorders,positive history of sensitivity to local anesthetic drugs,bradycardia ,pregnant and neursing women, seizure disorders,C.N.S problems and heart blocks . patients in whom more than 15 sec were required for tracheal intubation were excluded from the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
B.I.S index. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: monitoring of depth of anesthesia.;Systolic Blood pressur. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: mmhg by NIBP Monitoring.;Diastolic Blood pressur. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: mmgh by NIBP manitoring.;Heart Rate. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: Heart Rate by electronic monitoring.	—

Measure

Time frame

B.I.S index. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: monitoring of depth of anesthesia.;Systolic Blood pressur. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: mmhg by NIBP Monitoring.;Diastolic Blood pressur. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: mmgh by NIBP manitoring.;Heart Rate. Timepoint: Before and 3 minutes after induction of anesthesia and 1,3.10minutes after intubation ,incision of surgery and every 15 minutes till the end of operation. Method of measurement: Heart Rate by electronic monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Ali Haghbin

Kerman University of Medical sciences

m.a.haghbin@gmail.com+98 34 1211 5780

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026