The effect of addition of Spironolactone to Enalapril on urinary albumin loss in diabetic patients.

The effect of adding Spironolactone to Enalapril therapy on micro albuminuria due to diabetes.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201109067483N1

Enrollment

Registered

2011-12-08

Start date

2010-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proteinuria due to diabetic nephropathy in diabetes type 2. Non-insulin dependent diabetes mellitus

Interventions

Intervention 1: Enalapril, 25 mg pr os twice a day, to half of the patients. Intervention 2: Enalapril, 25 mg pr os twice a day and Spironolacton, 25 mg, per os, once a day, to half of the patients.

Treatment - Drugs

Enalapril, 25 mg pr os twice a day, to half of the patients.

Enalapril, 25 mg pr os twice a day and Spironolacton, 25 mg, per os, once a day, to half of the patients.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Diabetic nephropathy as micro-albuminuria, More than 18 years old, Less than 80 years old Exclusion criteria: Serum creatinine more than 2mg/dl, Serum Potassium more than 5.5 mmol/dl at any stage of the study, Cardiac ejection fraction less than 35%

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Urine Albumin. Timepoint: at the beginning and the end of the study. Method of measurement: by laboratory kit.;Urine Creatinine. Timepoint: at the beginning and the end of the study. Method of measurement: by laboratory kit.;Albumin on creatinine ratio. Timepoint: at the beginning and the end of the study. Method of measurement: by division of numeric amount of albumin on numeric amount of creatinine.	—

Measure

Time frame

Urine Albumin. Timepoint: at the beginning and the end of the study. Method of measurement: by laboratory kit.;Urine Creatinine. Timepoint: at the beginning and the end of the study. Method of measurement: by laboratory kit.;Albumin on creatinine ratio. Timepoint: at the beginning and the end of the study. Method of measurement: by division of numeric amount of albumin on numeric amount of creatinine.

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Secondary

Measure	Time frame
Systolic blood pressure. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: by sphygmomanometer (mmHg).;Serum potassium. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: by laboratory kit (mmol/dl).;Glumerular filteration ration (GFR). Timepoint: at the beginning and the end of the study. Method of measurement: by MDRD method (Modification of Diet in Renal Disease).;Body weight. Timepoint: at the beginning and the end of the study. Method of measurement: medical weighing scale(Kg).;Diastolic blood pressure. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: Sphygmomanometer (mmHg).	—

Measure

Time frame

Systolic blood pressure. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: by sphygmomanometer (mmHg).;Serum potassium. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: by laboratory kit (mmol/dl).;Glumerular filteration ration (GFR). Timepoint: at the beginning and the end of the study. Method of measurement: by MDRD method (Modification of Diet in Renal Disease).;Body weight. Timepoint: at the beginning and the end of the study. Method of measurement: medical weighing scale(Kg).;Diastolic blood pressure. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: Sphygmomanometer (mmHg).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Amir Abbas Vaezi

Qazvin university of medical sciences

avaezi@qum.ac.ir+98 28 1336 0084

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026