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Effect of Benson's sedation on nitroglycerin-induced headache

The effect of Benson's relaxation on range of headache-induced by intravenous infusion of nitroglycerin in acute coronary syndrome patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110906007494N47
Enrollment
60
Registered
2025-05-14
Start date
2025-03-25
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome. Acute coronary thrombosis not resulting in myocardial infarction

Interventions

Intervention 1: Intervention group: For the intervention group, the sedation method will be performed by the researcher on the bed in Fatemeh Zahra Hospital in Sari. This intervention will be performe
so that the intervention group will receive sedation despite the standard treatment (injection of one gram of intravenous acetaminophen or Apotel) (9). Intervention 2: Control group: The control group
however, they will not receive any sedative intervention. Headache measurements in the control group will be performed similarly to those in the intervention group at 15, 35, and 60 minutes after the

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: A new diagnosis of ACS Age above 18 years No migraine headaches and any other headaches No drug addiction Absence of neurological disorders under drug treatment Absence of headache before starting nitroglycerin injection Absence of pain in other parts of the body (except chest pain) Absence of speech and vision disorders Not using oral and topical nitrate drugs

Exclusion criteria

Exclusion criteria: Lack of ability due to increased chest pain and confusion of the patient's hemodynamic symptoms (sbp<100, p<60) The need to increase the dose of nitroglycerin received (more than 5 micrograms per minute) Lack of cooperation with the researcher

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: For both the intervention and control groups, The first headache measurement will be done 15 minutes after the start of intravenous nitroglycerin infusion (before the intervention). The second measurement of headache will be done 35 minutes after the start of intravenous nitroglycerin infusion (immediately after the end of sedation) and the third measurement of headache will be done 60 minutes after the start of intravenous nitroglycerin infusion (after the intervention). Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Masoumeh Bagheri Nesami

Mazandaran University of Medical Sciences

anna3043@gmail.com+98 11 3379 5508

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026