traumatic spinal cord injury. Accidents
Conditions
Interventions
Intervention 1: in the intervention group subcutaneous administration of 300 mcg GCSF will be performed for 5 days. Intervention 2: in the control group subcutaneous administration of placebo (normal
Treatment - Drugs
Placebo
in the intervention group subcutaneous administration of 300 mcg GCSF will be performed for 5 days
in the control group subcutaneous administration of placebo (normal saline) will be performed for 5 days
Sponsors
Brain and Spinal Injury Research Center, Tehran university of medical sciences
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1.Patients must be able to give voluntary consent; 2-Age between 20 to 40 years old; 3-Time between injury and enrollment greater than 1 year; 4-No evidence of cord compression, disc herniation, cord atrophy and angulation deformity on the performed MRI; 5-no evidence of lower motor neuron injury; 6-no evidence of ossification; 7-optimized SCIM questionnaire score; 8-not using indwelling catheterization; 9-no evidence of any other systemic or psychological disorder; 10-no evidence of bedsore; 11-normal Complete Blood Count; 12- evidence of incomplete spinal cord injury according to the American Spinal Injury Association Impairment Scale. Exclusion criteria: 1-evidence of drug side effects; 2-past history of hematologic disorders in patients or patients’ first degree relatives.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensory level score, motor score. Timepoint: before the intervention, 1st, 3rd, 6th and 12th months of study. Method of measurement: according to American Spinal Injury Association (ASIA) impairment scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Independent life ability. Timepoint: before the intervention, 1st, 3rd, 6th and 12th months of study. Method of measurement: Spinal Cord Independence Measure III. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Hooshang Saberi
Tehran University of Medical Sciences
Outcome results
None listed