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Effect of nano hydroxyapatite toothpaste and mouthwash on enamel and dentin erosion

Effect of nano hydroxyapatite toothpastes and mouth rinse on eroded enamel and dentin - an in situ study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110823007402N9
Enrollment
21
Registered
2023-01-23
Start date
2023-04-05
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

enamel and dentin erosion. Erosion of teeth

Interventions

Intervention 1: The first intervention group (positive control): using Elmex ® erosion protection toothpaste (GABA International AG, Therwil, Switzerland) containing 3500 ppm of tin ions in the form o

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Being at least 18 years old 2) Having good general and oral health 3) Not being allergic to certain substances including oral hygiene products or dental materials 4) Non-stimulated and stimulated saliva flow more than 0.25 ml/min and more than 0.25 ml/min, respectively. 5) The absence of active caries lesions or non-carious lesions such as cervical lesions and periodontal disease 6) The absence of dental prostheses and orthodontic appliances 7) The absence of erosive lesions in the teeth 8) The possibility of visiting at recalls.

Exclusion criteria

Exclusion criteria: 1) Pregnancy or intention to become pregnant during the study 2) Breastfeeding 3) Simultaneous participation in another study 4) Professional use of fluoride in the last two months 5) Inability to implement the study protocols 6) Receiving medical treatment 7) Using drugs that Interference with the flow of saliva 8) Having digestive problems 9) Smoking

Design outcomes

Primary

MeasureTime frame
Surface microhardness, roughness and surface wear. Timepoint: 5 days after the erosive/abrasive challenge. Method of measurement: Measuring surface wear with contact profilometry, surface hardness using Vickers test, surface roughness with atomic force microscope.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahtab Memarpour

Shiraz University of Medical Sciences

memarpour@sums.ac.ir+98 71 1626 3192

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026