Recurrent implantation failure.
Conditions
Interventions
Intervention 1: Placebo group: 40 patients who have infusion of N/S in the day of OPU. Intervention 2: Case group: 40 patients who have infusion of GCSF in the day of OPU. Intervention 3: Control g
Treatment - Drugs
Placebo group: 40 patients who have infusion of N/S in the day of OPU
Case group: 40 patients who have infusion of GCSF in the day of OPU
Control group:patients who follow the normal cycle without
any intervention
Sponsors
Vice chancellor of research of TUMS
Eligibility
Sex/Gender
Female
Age
25 Years to 43 Years
Inclusion criteria
Inclusion criteria: Patients with RIF, aged 25-40 years, were recruited for this prospective study. RIF was defined as the failure of good quality embryos (grade I or II) to implant after at least 3 cycles of IVF/ICSI in infertile women without thrombophila and anatomic abnormalities of uterine cavity. Exclusion criteria:patients who have sensitivity to GCSF
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrauterin infusion of GCS-F (300mcg) in day of oocyte pick up. Timepoint: Chemical pregnancy. Method of measurement: Measuerment of B-HCG 14 days after embryo transfer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy. Timepoint: 5 weeks after LMP. Method of measurement: Gestational sac in transvaginal sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Davari Tanha
Tehran University of Medical Sciences
Outcome results
None listed