The effect of oral clonidine on postoperative pain

The effect of low dose oral clonidine on postoperative pain in patients undergoing abdominal hysterectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108202963N3

Enrollment

Registered

2012-03-17

Start date

2011-04-12

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CLONIDINE. Other antihypertensive drugs, not elsewhere classified

Interventions

Intervention 1: clonidine 100 microgram, orally 2 hours before surgery. Intervention 2: placebo 2 hours before surgery.

Treatment - Drugs

Placebo

clonidine 100 microgram, orally 2 hours before surgery

placebo 2 hours before surgery

Eligibility

Sex/Gender

Female

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: women with American Society of Anesthesia (ASA) physical status I or II who are candidate for elective abdominal hysterectomy, age 40-65years old, BMI <35 Exclusion criteria: patients with mental impairment,chronic pain ,a history of congestive heart failure ,valvular heart disease,renal or hepatic disease,psychiatric disease ,addiction were excluded.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: 2,6,12,24 hours postoperatively. Method of measurement: visual analog pain score.;The first request of the patient for analgesic. Timepoint: during 24 hours after operation. Method of measurement: in hours.;Opioid consumption. Timepoint: during 24 hours after operation. Method of measurement: mg morphine.	—

Secondary

Measure	Time frame
Heart rates. Timepoint: before induction of anesthesia ,immediately and then 5 , 30 minutes after laryngoscopy and intubation and in the recovery room. Method of measurement: beats per minute.;Systolic blood pressures. Timepoint: before induction of anesthesia ,immediately and then 5 , 30 minutes after laryngoscopy and intubation and in the recovery room. Method of measurement: In mnHg by Sphyngomanometer.;Side effects of clonidine (headache,pruritis,dizziness). Timepoint: 1, 6, 12 and 24 hours after operation. Method of measurement: asking the patient.	—

Measure

Time frame

Heart rates. Timepoint: before induction of anesthesia ,immediately and then 5 , 30 minutes after laryngoscopy and intubation and in the recovery room. Method of measurement: beats per minute.;Systolic blood pressures. Timepoint: before induction of anesthesia ,immediately and then 5 , 30 minutes after laryngoscopy and intubation and in the recovery room. Method of measurement: In mnHg by Sphyngomanometer.;Side effects of clonidine (headache,pruritis,dizziness). Timepoint: 1, 6, 12 and 24 hours after operation. Method of measurement: asking the patient.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShekoufeh Behdad

Shahid Sadoughi University of Medical Sciences

drbehdad@yahoo.com+98 35 1822 4104

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026