Effectiveness of Aripiprazole in Acute Mania

Comparing the Efficacy of Aripiprazole with other Second-Generation Antipsychotics in Acute Mania Symptoms in Manic Patients

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110819007373N8

Enrollment

Registered

2018-12-29

Start date

2018-12-05

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Manic. Manic episode without psychotic symptoms

Interventions

Intervention 1: Intervention group: Aripiprazole is used in these patients, initiating treatment with aripiprazole at a dose of 5 to 15 mg per day, after two weeks, the dose is increased to 5 mg, also

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with bipolar I disorder in the phase of mania Age older than 18 years Satisfaction for the study

Exclusion criteria

Exclusion criteria: Patients who have used anti-psychotic medicines for the past 30 days Patients who have been using ECT for the past 6 months Patients who are pregnant or breast-feeding Patients with alcohol dependence Cognitive impairment other than bipolar disorder High risk of suicide The use of medication stabilizers other than sodium valproate liver disorders The history of polycystic ovaries Thrombocytopenia

Design outcomes

Primary

Measure	Time frame
Symptoms of acute mania. Timepoint: Initially and 2, 4 and 6 weeks. Method of measurement: Using Yang Mania Rating Scale (YMRS), Clinical Global Impression Questionnaire (CGI) and Young Mania Rating Scale (YMRS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Jamilian

Arak University of Medical Sciences

jamilian.hr@arakmu.ac.ir+98 86 3313 5075

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026