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New regimen of therapy in the treatment of Bronchiolitis

Comparison safety and efficacy of Phnylephrine with placebo in treatment of hospitalized children with bronchiolitis

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201108187371N1
Enrollment
100
Registered
2011-09-29
Start date
2010-11-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bronchiolitis. acute bronchiolitis

Interventions

Intervention 1: First group (A) received routine treatment of bronchiolitis and also received a drop phenyephrin 0.5% in supine position that remained in this position for 1 min. Intervention 2: The s
Treatment - Drugs
First group (A) received routine treatment of bronchiolitis and also received a drop phenyephrin 0.5% in supine position that remained in this position for 1 min.
The second group (B) received routine treatment of bronchiolitis and also recieved drop NaCl 0.9% in supine position that remained in this position for 1 min. Thirty minutes after administration of dr

Sponsors

Vice chancellory for Research, Zahedan University of Medical Sceiences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ages 4 weeks to 12 months; clinical diagnosis of viral bronchiolitis as the primary reason for hospitalization; presence of an oxygen requirement and a minimum severity score of 1. Exclusion criteria: history of chronic neurologic, heart, kidney, or lung disease; history of prematurity 10; use of nebulized albuterol or nebulized epinephrine within 4 hours of study enrollment; use of nasal phenylephrine or oxymetazoline within 12 hours of study enrollment; or “unstable” vital signs. “Unstable” vital signs are defined as heart rate >200 beats/min, blood pressure 2 standard deviations above or below the age appropriate mean, and respiratory rate above 80 breaths/min. The choice of maximum score is somewhat arbitrary but would exclude patients with all of the following: respiratory rate =70 breaths/min; intercostal, substernal and supraclavicular retractions; no feeding; and inspiratory and expiratory wheezing or diminished breath sounds.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Respiratory distress. Timepoint: 30 minutes after completion of therapy. Method of measurement: physical examination.

Secondary

MeasureTime frame
Pulse rate. Timepoint: 30 minutes after completion of therapy. Method of measurement: physical examination.;O2 saturation. Timepoint: 30 minutes after completion of therapy. Method of measurement: physical examination.;Dyspenea. Timepoint: 30 minutes after completion of therapy. Method of measurement: physical examination.;Retraction. Timepoint: 30 minutes after completion of therapy. Method of measurement: physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Akbarpour

Zahedan University of Medical Sciences

akbarpoorm@zaums.ac.ir , Pardis_10107@yahoo.com+98 54 1341 1260

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026