Polycystic ovary syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Control
group(1):
Treated with metformin tablets (500 mg twice daily).Treated for 6 months. Intervention 2: Intervention: group(2):Treated with metformin tablets (500 mg twice dail
Treatment - Drugs
Control
group(1):
Treated with metformin tablets (500 mg twice daily).Treated for 6 months.
Intervention: group(2):Treated with metformin tablets (500 mg twice daily) with supplements of vitamin B12 (1000 micrograms weekly injections), will be treated for 6 months.
Intervention: group(3):Treated with metformin tablets (500 mg twice daily) with folic acid supplements (1 mg daily), will be treated for 6 months.
Sponsors
Vice Chancellor for Research and Technology, Babol University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
17 Years to 35 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with PCOs aged 17-35 years. Exclusion criteria: Patients with each background of malady (such as, cardiovascular diseases, diabetes, congenital adrenal hyperplasia,…); using of drugs anti-pregnancy, hormonal, anti-overweight and medications known to interfere with folic acid and vitamin B12 metabolism (such as, metotreksat, nitric oxide and Azaribine), history of hypertension, high activity of body, alcoholic, smoker and subjects with > 120 mg/ml serum folic acid and =1000 pg/ml vitamin B12 than normal ranges.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperhomocysteinaemia. Timepoint: During the period of six months after treatment. Method of measurement: clinical and laboratory findings.;Hyperinsulinaemia. Timepoint: During the period of six months after treatment. Method of measurement: clinical and laboratory findings. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum folic acid levels. Timepoint: Six months after starting treatment. Method of measurement: laboratory findings.;Serum vitamin B12 levels. Timepoint: Six months after starting treatment. Method of measurement: laboratory findings.;Serum homocysteine(HCY) ??levels. Timepoint: Six months after starting treatment. Method of measurement: laboratory findings. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNargess Gholizadeh Pasha
Fatemehzahra Fertility & reproductive Health Research Center
Outcome results
None listed