osteoporosis. Postmenopausal osteoporosis with pathological fracture
Conditions
Interventions
Intervention 1: At the first line in this study we do the bone densitometry in all patients in drug group to determine the severity of osteoporosis and also these laboratory tests as serum creatinine,
Treatment - Drugs
Placebo
At the first line in this study we do the bone densitometry in all patients in drug group to determine the severity of osteoporosis and also these laboratory tests as serum creatinine, serum Nitrogen-
At the first line in this study we do the bone densitometry in all patients in placebo group to determine the severity of osteoporosis and also these laboratory tests as serum creatinine, serum Nitrog
Sponsors
Arak University of Medical Science
Eligibility
Sex/Gender
Female
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: longer than 1 year that passed patient`s menopause; patients under treatment in the hemodialysis units or CKD patients with GFR<=60; age older than 35 years. The following exclusion criteria were applied: history of previous HRT; venous occlusive disease; previous history of arteriovenous ?stula thrombosis; cardiovascular disease; hepatic disease; cancer; patients had previous evidence of disease, other than chronic renal failure, that could affect bone metabolism; patients who had been recently treated with estrogen, progesterone, tibolone, corticosteroids, anticonvulsants, ?uoride, bisphosphonates, or calcitonin; withdrawal of raloxifen for more than 4weeks were excluded from the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of parathyroid hormone. Timepoint: baseline and 6 months after first sampling. Method of measurement: picogram/mililiter and by ELISA method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum calcium. Timepoint: baseline and 6 months after first sampling. Method of measurement: millgram/desiliter and photometery method.;Serum phosphorous. Timepoint: baseline nad 6 months after first sampling. Method of measurement: millgram/desiliter and photometery method.;Bone densitometery. Timepoint: baseline and 6 months after first sampling. Method of measurement: standard deviation(z-score and t-score) and DEXA method.;Fracture incidense. Timepoint: monthly after first sampling. Method of measurement: questionair and observational method.;Serum alkaline phosphatase. Timepoint: baseline and 6 months after first sampling. Method of measurement: unit/liter and photometery method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTahmineh Farbod Ara
Arak University of Medical Science
Outcome results
None listed