cardiac. Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
Conditions
Interventions
Intervention 1: The control group was injected only pure blood. But all routine procedures were performed for them. Blood samples (10 cc for each time ) were measured respectively for measurement of c
Treatment - Drugs
The control group was injected only pure blood. But all routine procedures were performed for them. Blood samples (10 cc for each time ) were measured respectively for measurement of cardiac enzymes a
Before the surgery all of the patients in both groups were inform about the benefits of this research and then, if they signed the consent form, will entrance to the study. Patients were assured that,
Sponsors
Vice Chancellor, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria were; not having another heart attack or another heart surgery at same time; no previous heart surgery; positive history of past severe disease; on-emergency surgery; the absence of high risk surgery; to abandon cases involving one vessel; uncontrolled diabetes; lack of severe left ventricular dysfunction; no MI with Q wave in 6 past weeks; lack of severe lesions of LM (greater than equal to 50%); unstable angina; non-cytotoxic drugs and radiation use; no recent blood transfusion in past month and willingness to participate in the study; Exiting criteria were; the operation of the on pump switch to off pump; addition of other surgery such as surgery aneurysmectomy LV; performed endarterctomy on the involved vessels ;prolonged clamping more than 100 minutes; prolonged pump more than 130 minutes; hemolysis of samples obtained from patients; clotting of samples taken from patients; lack of proper storage and transport of samples at the usual time; less than 5 / 1 cc of blood serum sample size..
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of cardiac enzymes and inflammatory factors. Timepoint: Oxidative stress markers in 5 stage and cardiac enzymes in 3 stage of surgery measured. Method of measurement: 10 cc of blood was taken in , before the bypass ,before opening the clamping, opening 10 minutes after clamping from the coronary sinus , first day and second day after surgery from venous blood . | — |
Secondary
| Measure | Time frame |
|---|---|
| Total serum antioxidant. Timepoint: Before ischemia and after reperfusion. Method of measurement: Total antioxidant capacity in serum using a commercial kit Ltd Randox Laboratories UK, CatNo.NX2332 were measured. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Alireza Yaghoubi
Tabriz University of Medical Sciences
Outcome results
None listed