Survey and comparison of the efficacy of Granisetron and Promethazine in control of Hyperemesis Gravidarum

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108144927N2

Enrollment

120

Registered

2011-08-16

Start date

2011-02-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperemesis gravidarum. Hyperemesis gravidarum with metabolic disturbance

Interventions

Intervention 1: Tab Promethazine 25mg qid (I.V. form in the first day of treatment). Intervention 2: Tab Granisetron 1mg bid (I.V. form in the first day of treatment).

Treatment - Drugs

Tab Promethazine 25mg qid (I.V. form in the first day of treatment)

Tab Granisetron 1mg bid (I.V. form in the first day of treatment)

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: the women in the 20 weeks of pregnancy; referred to gynecology and obstetrics emergency room in Dr.Shariati hospital; inappropriate response to outpatient antiemetic therapies; presenting more than one plus ketonuria in complete analysis of urine; nausea and vomiting score more than 13 (according to the pregnancy unique qualification of emesis) and signing the study written consent. Exclusion criteria: molar pregnancy and sever thyroid or liver disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea. Timepoint: 48 hours. Method of measurement: Physical examination.;Vomoting. Timepoint: 48 hours. Method of measurement: Physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ashraf Alyasin

Dr. Shariati Teaching Hospita

alyasina@sina.tums.ac.ir+98 21 8490 2421

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026