Topical Citrullus colocynthis fruit oil in painful peripheral diabetic neuropathy

Evaluation of topical Citrullus colocynthis fruit oil efficacy in the pain, electrodiagnostic findings and quality of life of patients with painful peripheral diabetic neuropathy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108117297N1

Enrollment

Registered

2015-01-19

Start date

2014-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Painful diabetic polyneuropathy. Diabetic polyneuropathy

Interventions

Intervention 1: Citrullus colocynthis fruit oil: 1cc three times per day, application on the plantar and dorsal foot surface , without massage. Intervention 2: Vehicle oil (Sesame oil): 1cc three time

Treatment - Drugs

Citrullus colocynthis fruit oil: 1cc three times per day, application on the plantar and dorsal foot surface , without massage

Vehicle oil (Sesame oil): 1cc three times per day, application on the plantar and dorsal foot surface , without massage

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Controlled type 1 or 2 diabetes mellitus; Painful Peripheral diabetic neuropathy for more than 3 months; Age more than 18 years old; Patients consent on enrolling study and admitting study protocol Exclusion criteria: Other causes of pain in lower extremities like lumbar disk herniation; Ulcerative lesions in lower extremities; Dermatitis; Pregnancy; Lactation; Citrullus colocynthis allergy; Unstable cardiac, neurological or renal disease; Diagnosed other types of neuropathy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Neuropathic Pain Scale (NPS) score. Timepoint: Before the study and 12 weeks after the intervention. Method of measurement: Visual Scale.	—

Secondary

Measure	Time frame
Nerve Conduction velocity. Timepoint: Before the study and 12 weeks after the intervention. Method of measurement: m/s by NCV.;WHOQOL-BREF score. Timepoint: Before the study and 12 weeks after the intervention. Method of measurement: Questionnaire (standard).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMojtaba Heydari

Shiraz University of Medical Sciences

meshkat_114@yahoo.com+98 71 1233 6541

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026